Davenport Lab

2022

Maher AK, Burnham KL, Jones EM, Tan MMH, Saputil RC, Baillon L, Selck C, Giang N, Argüello R, Pillay C, Thorley E, Short CE, Quinlan R, Barclay WS, Cooper N, Taylor GP, Davenport EE and Dominguez-Villar M
Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19.
Nature Communications 13 (1) 7947

Foguet C, Xu Y, Ritchie SC, Lambert SA, Persyn E, Nath AP, Davenport EE, Roberts DJ, Paul DS, Di Angelantonio E, Danesh J, Butterworth AS, Yau C and Inouye M
Genetically personalised organ-specific metabolic models in health and disease.
Nature Communications 13 (1) 7356

Cano-Gamez E, Burnham KL, Goh C, Allcock A, Malick ZH, Overend L, Kwok A, Smith DA, Peters-Sengers H, Antcliffe D, GAinS Investigators, McKechnie S, Scicluna BP, van der Poll T, Gordon AC, Hinds CJ, Davenport EE^† and Knight JC^†
An immune dysfunction score for stratification of patients with acute infection based on whole blood gene expression
Science Translational Medicine 14 (699) eabq4433

Abraham GR, Morrow AJ, Oliveira J, Weir-McCall JR, Davenport EE, Berry C, Davenport AP and Hoole SP
Mechanistic study of the effect of Endothelin SNPs in microvascular angina – Protocol of the PRIZE Endothelin Sub-Study
IJC Heart & Vasculature 39:100980

COvid-19 Multi-omics BLood ATlas (COMBAT) Consortium
A blood atlas of COVID-19 defines hallmarks of disease severity and specificity
Cell 185 (5) 916-938.e58

Pereverzeva L, Uhel F, Sengers HP, Butler J, van Vught LA, Burnham KL, Davenport EE, Knight JC, Cremer OL, Schultz MJ, Bonten MMJ, Scicluna BP and van der Poll T
Blood leukocyte transcriptomes in gram-positive and gram-negative community-acquired pneumonia
European Respiratory Journal 59 (3) 2101856

Cui J, Raychaudhuri S, Karlson EW, Speyer C, Malspeis S, Guan H, Sparks JA, Ni H, Liu X, Stevens E, Williams JN, Davenport EE, Knevel R, and Costenbader K. Interactions Between Genome-Wide Genetic Factors and Smoking Influencing Risk of Systemic Lupus Erythematosus
Arthritis & Rheumatology 72, 1863-1871

Amariuta T, Luo y, Gazal S, Davenport EE, van de Geijn B, Kazuyoshi I, Westra H-J, Teslovich N, Okada Y, Yamamoto K, RACI Consortium, GARNET Consortium, Price A and Raychaudhuri S.
IMPACT: Genomic annotation of cell-state-specific regulatory elements inferred from the epigenome of bound transcription factors
American Journal of Human Genetics 104, 879-895

Davenport EE, Amariuta T, Gutierrez-Arcelus M, Slowikowski K, Westra H-J, Luo Y, Shen C, Rao DA, Zhang Y, Pearson S, von Schack D, Beebe JS, Bing N, John S, Vincent MS, Zhang B and Raychaudhuri S.
Discovering in vivo cytokine eQTL interactions from a lupus clinical trial
Genome Biology 19, 168

Sweeney TE, Perumal TM, …Davenport EE… Khatri P, Tsalik EL, Mangravite LM and Langley RJ
A community approach to mortality prediction in sepsis via gene expression analysis
Nature Communications 9, 694

Scicluna BP, van Vught LA, Zwinderman AH, Wiewel MA, Davenport EE, Burnham KL, Nürnberg P, Schultz MJ, Horn J, Cremer OL, Bonten MJ, Hinds CJ, Wong HR, Knight JC and van der Poll T
Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study
The Lancet Respiratory Medicine 5, 816-826

Burnham KL, Davenport EE, Radhakrishnan J, Humburg P, Gordon AC, Hutton P, Svoren-Jabalera E, Garrard C, Hill AVS, Hinds CJ and Knight JC
Shared and Distinct Aspects of the Sepsis Transcriptomic Response to Fecal Peritonitis and Pneumonia
American Journal of Respiratory And Critical Care Medicine 196, 328-339

Davenport EE, Burnham KL, Radhakrishnan J, Humburg P, Hutton P, Mills TC, Rautanen A, Gordon AC, Garrard C, Hill AVS, Hinds CJ and Knight JC
Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study
The Lancet Respiratory Medicine 4, 259-271

Dhalla F, Fox H, Davenport EE, Sadler R, Anzilotti C, van Schouwenburg PA, Ferry B, Chapel H, Knight JC and Patel S
Chronic Mucocutaneous Candidiasis: characterization of a family with STAT1 gain-of-function and development of an ex vivo assay for Th17 dysfunction of diagnostic utility
Clinical and Experimental Immunology 184, 216-227

van Schouwenburg PA^*, Davenport EE^*, Kienzler A-K, Marwah I, Wright B, Lucas M, Malinasuskas T, Martin HC, WGS500 Consortium, Lockstone HE, Cazier J-B, Chapel HM, Knight JC and Patel SY
Application of whole genome and RNA sequencing to investigate the genomic landscape of common variable immunodeficiency
Clinical Immunology 160, 301-314

Taylor JC, Martin HC, …Davenport EE… Donnelly P and McVean G
Factors influencing success of clinical genome sequencing across a broad spectrum of disorders
Nature Genetics 47, 717-726

Davenport EE^*, Antrobus RD^*, Lillie PJ, Gilbert S and Knight JC
Transcriptomic profiling facilitates classification of response to influenza challenge
Journal Molecular Medicine 93, 105-114

Fairfax BP, Davenport EE, Makino S, Hill AVS, Vannberg FO, Knight JC
A common haplotype of the tumour necrosis factor receptor 2 gene modulates endotoxin tolerance
Journal of Immunology 186, 3058-3065

^* Co-first author ^† Co-corresponding